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Title:Computer Applications in Pharmaceutical Research and Development
Format Type:Ebook
Author:
Publisher:Wiley-Interscience
ISBN:0471737798
ISBN 13:
Number of Pages:805
Category:Manga

Computer Applications in Pharmaceutical Research and Development by Sean Ekins

PDF, EPUB, MOBI, TXT, DOC Computer Applications in Pharmaceutical Research and Development A unique holistic approach covering all functions and phases of pharmaceutical research and development .

While there are a number of texts dedicated to individual aspects of pharmaceutical research and development this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery development and marketing It explains how applications are used at various stages including bioinformatics data mining predicting human response to drugs and high throughput screening By providing a comprehensive view the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process .

Chapters are organized into the following sections Computers in pharmaceutical research and development a general overview Understanding diseases mining complex systems for knowledge Scientific information handling and enhancing productivity Computers in drug discovery Computers in preclinical development Computers in development decision making economics and market analysis Computers in clinical development Future applications and future development .

Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book Figures are used extensively to illustrate complex concepts and multifaceted processes References are provided in each chapter to enable readers to continue investigating a particular topic in depth Finally tables of software resources are provided in many of the chapters .

This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET drug discovery and technology development The book s cross functional all phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics

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Computational Toxicology: Risk Assessment for Chemicals, The Future of the Pharmaceutical Industry, Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools (Wiley Series on Technologies for the Pharmaceutical Industry #4), Computer Applications in Pharmaceutical Research and Development, Computational Toxicology: Risk Assessment for Chemicals, Collaborative Computational Technologies for Biomedical Research, Pharmaceutical and Biomedical Project Management in a Changing Global Environment, Computational Toxicology: Risk Assessment for Chemicals, Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals, The Engines of Hippocrates: From the Dawn of Medicine to Medical and Pharmaceutical Informatics
Methods Processes and Tools for Collaboration br br The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today This book describes how the computational sciences have transformed into being a key knowledge broker able to integrate and operate across divergent data types Bryn Williams Jones Associate Research Fellow Pfizer br br The pharmaceutical industry utilizes an extended network of partner organizations in order to discover and develop new drugs however there is currently little guidance for managing information and resources across collaborations br br Featuring contributions from the leading experts in a range of industries Collaborative Computational Technologies for Biomedical Research provides information that will help organizations make critical decisions about managing partnerships including br br br Serving as a user manual for collaborations br br Tackling real problems from both human collaborative and data and informatics perspectives br br Providing case histories of biomedical collaborations and technology specific chapters that balance technological depth with accessibility for the non specialist reader br br A must read for anyone working in the pharmaceuticals industry or academia this book marks a major step towards widespread collaboration facilitated by computational technologies, A unique holistic approach covering all functions and phases of pharmaceutical research and development br br br While there are a number of texts dedicated to individual aspects of pharmaceutical research and development this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery development and marketing It explains how applications are used at various stages including bioinformatics data mining predicting human response to drugs and high throughput screening By providing a comprehensive view the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process br br Chapters are organized into the following sections br Computers in pharmaceutical research and development a general overview br Understanding diseases mining complex systems for knowledge br Scientific information handling and enhancing productivity br Computers in drug discovery br Computers in preclinical development br Computers in development decision making economics and market analysis br Computers in clinical development br Future applications and future development br br Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book Figures are used extensively to illustrate complex concepts and multifaceted processes References are provided in each chapter to enable readers to continue investigating a particular topic in depth Finally tables of software resources are provided in many of the chapters br br This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET drug discovery and technology development The book s cross functional all phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics, A comprehensive analysis of state of the art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals br br This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer based tools utilizing X ray crystal structures or homology receptor pharmacophore and quantitative structure activity relationship QSAR models of human proteins It covers the in vitro models used newer technologies and regulatory aspects The book offers a complete systems perspective to risk assessment prediction discussing experimental and computational approaches in detail with br br An introduction to toxicology methods and an explanation of computational methods br br In depth reviews of QSAR methods applied to enzymes transporters nuclear receptors and ion channels br br Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena br br Chapters written by leading international experts br br Figures that illustrate computational models and references for further information br br This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET drug discovery and technology and software development, This book covers key emerging technologies detailed under About the Topic in pharmaceutical R amp D and how they have substantially impacted or are currently impacting drug discovery The cross disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations This book cuts across the multiple areas of drug discovery each chapter authored by pioneers in that field making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development